We help our biotech customers mainly by providing them with Speciality solutions in ADME and our Pharma customers by providing them capacity as in Bottleneck Solutions.

Speciality solutions

Study planning: We help you to find the most suitable ADME studies to answer questions relevant for you project/molecule and keep you updated about the FDA recommendations.

Cascade plans: We help you to decide in which order various studies should be carried out, also when you use another CRO as a study provider.

Go / no-go criteria selection: We can give you intelligence support in putting together information from different studies and deciding which molecules take further and which discard.

Analytical method development: we will find optimum conditions for your molecules in both quantitative and qualitative work.

In vitro and in vivo ADME study execution: We carry out a wide range of ADME studies, and also just parts of studies, like analytics.

Result interpretation: We will crack down the numbers for you and help you to see beyond the data and observations. This service is available also for the data you have created yourself or you have obtained from another CRO.

Reporting: Like all the ITS services also our reporting is taylorable so that you have all the information in the format most suitable to you.

Recommendation of future studies: If there is still an important issue that needs to be checked up for your NCE, we will include a recommendation for a suitable study in our reports. This service is also available for your own inhouse or other outsourced projects.

Please find comprehensive list of available studies here.

Order a price list or request a quotation here.

Bottleneck solutions

We provide you with capacity and on-time delivery especially in the area of metabolism and drug interaction studies.

Instead of MS/MS instruments more suitable for quantitative work, we define metabolic profiles and identify metabolites with TOF-MS. Your advantage here is massive savings in time.

Any work in this area can be tailored according to your needs.

• Metabolite identification, in vitro and in vivo: special expertise
• In vitro metabolic stability, multi-species
• CYP inhibition, cocktail approach
• Early DMPK (in-life/bioanalytics/PK calculations), multi-species

• PhysChem properties: pKa, LogD, solubility
• Protein binding and stability, multi-species

• Membrane permeability with PAMPA and Caco-2
• ATPase assays for efflux/transporter interaction

Please find comprehensive list of available studies here.

Order a price list or request a quotation here.